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TOPROL-XL, metoprolol succinate, is a beta 1 -selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets.

Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 23.75, 47.5, 95 and 190 mg of metoprolol succinate equivalent to 25, 50, 100 and 200 mg of metoprolol tartrate, USP, respectively. Its chemical name is () 1-( isopropylamino)-3-[ p-( 2-methoxyethyl) phenoxy]-2-propanol succinate (2: 1) (salt).

WARNINGS

Ischemic Heart Disease

Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1Ð 2 weeks and the patient should be carefully monitored.

If angina markedly worsens or acute coronary insufficiency develops, TOPROL-XL administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue TOPROL-XL therapy abruptly even in patients treated only for hypertension.

INDICATIONS AND USAGE

Hypertension TOPROL-XL is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Angina Pectoris TOPROL-XL is indicated in the long-term treatment of angina pectoris.

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Side Effects of TOPROL-XL

Once-a-day TOPROL-XL may be be prescribed by your doctor to treat patients with high blood pressure (hypertension), angina pectoris (chest pain) over the long term, and stable, symptomatic Class II or Class III heart failure that is caused by high blood pressure (hypertension), blocked heart arteries, or other heart muscle disorders. It was studied in patients who were already taking other medications for heart failure.

The information below is meant to help you understand the most common side effects of TOPROL-XL and any special concerns regarding this medication. If you have any questions about TOPROL-XL or any of your current medications, be sure to talk to your doctor or other health care provider.

What side effects may I notice from taking metoprolol? (toprol xl)
Side effects that you should report to your prescriber or health care professional as soon as possible:
•anxiety
•cold, tingling, or numb hands or feet
•difficulty breathing, wheezing
•dizziness or fainting spells
•increase in the amount of urine passed
•increased thirst
•irregular heartbeat
•skin rash
•slow heart rate (fewer than recommended by your prescriber or health care professional)
•sweating
•swollen legs or ankles
•tremor, shakes
•vomiting
•weight loss

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
•diarrhea
•dry itching skin
•headache
•nausea
•sexual difficulties, impotence
•unusual tiredness

Why is Lopressor prescribed?

Lopressor(toprol xl), a type of medication known as a beta blocker, is used in the treatment of high blood pressure, angina pectoris (chest pain, usually caused by lack of oxygen to the heart due to clogged arteries), and heart attack. When prescribed for high blood pressure, it is effective when used alone or in combination with other high blood pressure medications. Beta blockers decrease the force and rate of heart contractions, thereby reducing the demand for oxygen and lowering blood pressure.