Toprol xl,generic for toprol xl 50 mg

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norisk Toprol xl,generic for toprol xl 50 mg

TOPROL-XL, metoprolol succinate, is a beta 1 -selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets.

Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 23.75, 47.5, 95 and 190 mg of metoprolol succinate equivalent to 25, 50, 100 and 200 mg of metoprolol tartrate, USP, respectively. Its chemical name is () 1-( isopropylamino)-3-[ p-( 2-methoxyethyl) phenoxy]-2-propanol succinate (2: 1) (salt).

WARNINGS

Ischemic Heart Disease

Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1Ð 2 weeks and the patient should be carefully monitored.

If angina markedly worsens or acute coronary insufficiency develops, TOPROL-XL administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue TOPROL-XL therapy abruptly even in patients treated only for hypertension.

INDICATIONS AND USAGE

Hypertension TOPROL-XL is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Angina Pectoris TOPROL-XL is indicated in the long-term treatment of angina pectoris.

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